The Guidelines expand upon TUE-related matters in the World Anti-Doping Code (Code) and the ISTUE. These Guidelines outline key ADO responsibilities, including support for athletes who need to make TUE applications, Therapeutic Use Exemption Committee (TUEC) decision-making guidelines, recognition of TUEs and communication of TUE decisions. Confidentiality provisions and the role of WADA in the review of TUE decisions are also addressed. The Guidelines are intended to provide clarity and additional guidance to the Code and the ISTUE. Unlike the Code and ISTUE, the Guidelines are not a mandatory document. In the event of conflict between the Code and/or the ISTUE and the Guidelines, the Code and/or ISTUE (as applicable) must prevail.