The 11th edition of The World Games took place in Birmingham, Alabama, USA from 7th to 17th July 2022. This edition, originally planned for 2021, was postponed to 2022 because of the impact of the COVID-19 pandemic.
The hosts expected around 3,600 athletes from over 100 countries. For the first time, the Iroquois team in Lacrosse represented an indigenous ethnic group. The distribution between women and men was about 50:50. Thirty-four sports were included in the ten days of competition. The athletes competed for the gold medals of The World Games in 223 medal events.
The ITA was responsible for the delivery of the anti-doping program for this event and collaborated with the Birmingham Organising Committee (BOC) for the on-site sample collection operations and connected logistical activities.